5-hydroxytryptamine receptor 2A
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5- dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.
Database | Links |
---|---|
UniProt | P28223 |
PDB | Not available |
BioGrid | 109588 |
BindingDB | P28223 |
DrugBank | DB01238, DB00477, DB01239, DB00604, DB01242, DB00363, DB00924, DB00434, DB00320, DB00843, DB00751, DB00696, DB00176, DB00933, DB00247, DB06148, DB00805, DB00370, DB01149, DB00334, DB01267, DB00715, DB00433, DB00420, DB01069, DB00777, DB01224, DB00734, DB06144, DB00372, DB00679, DB00752, DB00656, DB00285, DB00246 |
Guide to PHARMACOLOGY | 6 |
PharmGKB | PA193 |
KEGG | hsa:3356 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3356 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9562 | 0.0011 |
Accuracy | 0.9019 | 0.0026 |
Sensitivity | 0.8858 | 0.0041 |
Specificity | 0.9154 | 0.0028 |
BEDROC | 0.9613 | 0.0054 |
MCC Threshold | 0.404 | N/A |
MCC | 0.8007 | N/A |
F-score Threshold | 0.404 | N/A |
F-score | 0.894 | N/A |