5-hydroxytryptamine receptor 1B
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Database | Links |
---|---|
UniProt | P28222 |
PDB | 2G1X, 4IAQ, 4IAR |
BioGrid | 109583 |
BindingDB | P28222 |
DrugBank | DB00918, DB01191, DB00320, DB00216, DB00696, DB00998, DB00952, DB00960, DB00571, DB00953, DB00669, DB00285, DB00315 |
Guide to PHARMACOLOGY | 2 |
PharmGKB | PA29549 |
KEGG | hsa:3351 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3351 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9733 | 0.0011 |
Accuracy | 0.9315 | 0.0018 |
Sensitivity | 0.9037 | 0.0034 |
Specificity | 0.9572 | 0.0031 |
BEDROC | 0.993 | 0.0035 |
MCC Threshold | 0.444 | N/A |
MCC | 0.8703 | N/A |
F-score Threshold | 0.444 | N/A |
F-score | 0.9318 | N/A |