TargetNet
P28221
5-hydroxytryptamine receptor 1D
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
Database Links
| Database | Links |
|---|---|
| UniProt | P28221 |
| PDB | Not available |
| BioGrid | 109584 |
| BindingDB | P28221 |
| DrugBank | DB00918, DB00320, DB00216, DB00696, DB00998, DB00952, DB00953, DB00669, DB01079, DB00246, DB00315 |
| Guide to PHARMACOLOGY | 3 |
| PharmGKB | PA29550 |
| KEGG | hsa:3352 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3352 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9822 | 0.0013 |
| Accuracy | 0.9403 | 0.0026 |
| Sensitivity | 0.917 | 0.0051 |
| Specificity | 0.9626 | 0.0035 |
| BEDROC | 0.9992 | 3.4784 × 10-4 |
| MCC Threshold | 0.432 | N/A |
| MCC | 0.8883 | N/A |
| F-score Threshold | 0.432 | N/A |
| F-score | 0.9425 | N/A |