TargetNet
P27815
cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Database Links
| Database | Links |
|---|---|
| UniProt | P27815 |
| PDB | 2QYK, 3I8V, 3TVX |
| BioGrid | 111167 |
| BindingDB | P27815 |
| DrugBank | DB01166, DB00975, DB00651, DB00824, DB01088, DB00235, DB00806, DB00692, DB00820, DB00277 |
| Guide to PHARMACOLOGY | 1300 |
| PharmGKB | PA33128 |
| KEGG | hsa:5141 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5141 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9722 | 0.0032 |
| Accuracy | 0.9279 | 0.004 |
| Sensitivity | 0.9139 | 0.0059 |
| Specificity | 0.9402 | 0.0044 |
| BEDROC | 0.9933 | 0.0031 |
| MCC Threshold | 0.48 | N/A |
| MCC | 0.8638 | N/A |
| F-score Threshold | 0.48 | N/A |
| F-score | 0.9271 | N/A |