Amine oxidase [flavin-containing] B
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
Database | Links |
---|---|
UniProt | P27338 |
PDB | 1GOS, 1H8R, 1OJ9, 1OJA, 1OJC, 1OJD, 1S2Q, 1S2Y, 1S3B, 1S3E, 2BK3, 2BK4, 2BK5, 2BYB, 2C64, 2C65, 2C66, 2C67, 2C70, 2C72, 2C73, 2C75, 2C76, 2V5Z, 2V60, 2V61, 2VRL, 2VRM, 2VZ2, 2XCG, 2XFN, 2XFO, 2XFP, 2XFQ, 2XFU, 3PO7, 3ZYX, 4A79, 4A7A |
BioGrid | 110302 |
BindingDB | P27338 |
DrugBank | DB00915, DB01156, DB00190, DB00215, DB00988, DB00494, DB00614, DB01381, DB01050, DB00458, DB04818, DB01247, DB01235, DB00934, DB00737, DB01171, DB00184, DB01626, DB00780, DB00191, DB01367, DB01037, DB00752 |
Guide to PHARMACOLOGY | 2490 |
PharmGKB | PA237 |
KEGG | hsa:4129 |
BioCyc | MetaCyc:HS00966-MONOMER |
Entrez Gene (GeneID) | 4129 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9194 | 0.0038 |
Accuracy | 0.8584 | 0.0053 |
Sensitivity | 0.8692 | 0.0058 |
Specificity | 0.8472 | 0.0078 |
BEDROC | 0.9473 | 0.0078 |
MCC Threshold | 0.55 | N/A |
MCC | 0.7281 | N/A |
F-score Threshold | 0.55 | N/A |
F-score | 0.8648 | N/A |