TargetNet
P26684
Endothelin-1 receptor
Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Database Links
| Database | Links |
|---|---|
| UniProt | P26684 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P26684 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 219 |
| PharmGKB | Not available |
| KEGG | rno:24326 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24326 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9787 | 0.0021 |
| Accuracy | 0.9387 | 0.0045 |
| Sensitivity | 0.9629 | 0.0079 |
| Specificity | 0.9167 | 0.0039 |
| BEDROC | 0.9927 | 0.0033 |
| MCC Threshold | 0.474 | N/A |
| MCC | 0.888 | N/A |
| F-score Threshold | 0.474 | N/A |
| F-score | 0.9421 | N/A |