TargetNet
P25929
Neuropeptide Y receptor type 1
Function
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.
Database Links
| Database | Links |
|---|---|
| UniProt | P25929 |
| PDB | 2F1U, 2IIL |
| BioGrid | 110946 |
| BindingDB | P25929 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 305 |
| PharmGKB | PA258 |
| KEGG | hsa:4886 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4886 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.908 | 0.0025 |
| Accuracy | 0.866 | 0.0028 |
| Sensitivity | 0.8023 | 0.0029 |
| Specificity | 0.9313 | 0.0049 |
| BEDROC | 0.9839 | 0.0091 |
| MCC Threshold | 0.496 | N/A |
| MCC | 0.7434 | N/A |
| F-score Threshold | 0.444 | N/A |
| F-score | 0.8644 | N/A |