TargetNet
P25779
Cruzipain
Function
Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.
Database Links
| Database | Links |
|---|---|
| UniProt | P25779 |
| PDB | 1AIM, 1EWL, 1EWM, 1EWO, 1EWP, 1F29, 1F2A, 1F2B, 1F2C, 1ME3, 1ME4, 1U9Q, 2AIM, 2OZ2, 3HD3, 3I06, 3IUT, 3KKU, 3LXS, 4KLB |
| BioGrid | Not available |
| BindingDB | P25779 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | Not available |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8937 | 0.0106 |
| Accuracy | 0.8225 | 0.0097 |
| Sensitivity | 0.7949 | 0.0146 |
| Specificity | 0.8528 | 0.0144 |
| BEDROC | 0.9809 | 0.0083 |
| MCC Threshold | 0.72 | N/A |
| MCC | 0.6564 | N/A |
| F-score Threshold | 0.48 | N/A |
| F-score | 0.8202 | N/A |