TargetNet
P25774
Cathepsin S
Function
Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
Database Links
| Database | Links |
|---|---|
| UniProt | P25774 |
| PDB | 1BXF, 1GLO, 1MS6, 1NPZ, 1NQC, 2C0Y, 2F1G, 2FQ9, 2FRA, 2FRQ, 2FT2, 2FUD, 2FYE, 2G6D, 2G7Y, 2H7J, 2HH5, 2HHN, 2HXZ, 2OP3, 2R9M, 2R9N, 2R9O, 3IEJ, 3KWN, 3MPE, 3MPF, 3N3G, 3N4C, 3OVX |
| BioGrid | 107900 |
| BindingDB | P25774 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2353 |
| PharmGKB | PA27041 |
| KEGG | hsa:1520 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1520 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9787 | 0.0022 |
| Accuracy | 0.9464 | 0.0021 |
| Sensitivity | 0.9367 | 0.0036 |
| Specificity | 0.9559 | 0.0041 |
| BEDROC | 0.9945 | 0.0029 |
| MCC Threshold | 0.536 | N/A |
| MCC | 0.8989 | N/A |
| F-score Threshold | 0.534 | N/A |
| F-score | 0.9484 | N/A |