TargetNet
P25116
Proteinase-activated receptor 1
Function
High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Database Links
| Database | Links |
|---|---|
| UniProt | P25116 |
| PDB | 1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 3BEF, 3HKI, 3HKJ, 3LU9, 3VW7 |
| BioGrid | 108448 |
| BindingDB | P25116 |
| DrugBank | DB00086 |
| Guide to PHARMACOLOGY | 347 |
| PharmGKB | PA27946 |
| KEGG | hsa:2149 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 2149 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9685 | 0.0019 |
| Accuracy | 0.9056 | 0.0035 |
| Sensitivity | 0.915 | 0.0057 |
| Specificity | 0.8958 | 0.0064 |
| BEDROC | 0.9982 | 0.0014 |
| MCC Threshold | 0.544 | N/A |
| MCC | 0.8263 | N/A |
| F-score Threshold | 0.442 | N/A |
| F-score | 0.9156 | N/A |