TargetNet
P25105
Platelet-activating factor receptor
Function
Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P25105 |
| PDB | 2B0X |
| BioGrid | 111696 |
| BindingDB | P25105 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 334 |
| PharmGKB | PA33933 |
| KEGG | hsa:5724 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 5724 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9774 | 0.0014 |
| Accuracy | 0.9327 | 0.0025 |
| Sensitivity | 0.9488 | 0.0028 |
| Specificity | 0.9133 | 0.0044 |
| BEDROC | 0.9974 | 0.0012 |
| MCC Threshold | 0.528 | N/A |
| MCC | 0.874 | N/A |
| F-score Threshold | 0.528 | N/A |
| F-score | 0.9434 | N/A |