TargetNet
P25103
Substance-P receptor
Function
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
Database Links
| Database | Links |
|---|---|
| UniProt | P25103 |
| PDB | 2KS9, 2KSA, 2KSB |
| BioGrid | 112732 |
| BindingDB | P25103 |
| DrugBank | DB00673, DB01221, DB04894 |
| Guide to PHARMACOLOGY | 360 |
| PharmGKB | PA36302 |
| KEGG | hsa:6869 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6869 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9932 | 3.9288 × 10-4 |
| Accuracy | 0.9665 | 0.0019 |
| Sensitivity | 0.9747 | 0.0022 |
| Specificity | 0.9568 | 0.0022 |
| BEDROC | 0.9996 | 2.3599 × 10-4 |
| MCC Threshold | 0.542 | N/A |
| MCC | 0.9343 | N/A |
| F-score Threshold | 0.54 | N/A |
| F-score | 0.97 | N/A |