TargetNet
P25101
Endothelin-1 receptor
Function
Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
Database Links
| Database | Links |
|---|---|
| UniProt | P25101 |
| PDB | Not available |
| BioGrid | 108231 |
| BindingDB | P25101 |
| DrugBank | DB00559 |
| Guide to PHARMACOLOGY | 219 |
| PharmGKB | PA27617 |
| KEGG | hsa:1909 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1909 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9887 | 6.9039 × 10-4 |
| Accuracy | 0.9661 | 0.0014 |
| Sensitivity | 0.9768 | 0.0024 |
| Specificity | 0.9562 | 0.0017 |
| BEDROC | 0.9939 | 0.0025 |
| MCC Threshold | 0.552 | N/A |
| MCC | 0.9317 | N/A |
| F-score Threshold | 0.552 | N/A |
| F-score | 0.9647 | N/A |