TargetNet
P25025
C-X-C chemokine receptor type 2
Function
Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.
Database Links
| Database | Links |
|---|---|
| UniProt | P25025 |
| PDB | Not available |
| BioGrid | 109793 |
| BindingDB | P25025 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 69 |
| PharmGKB | PA29843 |
| KEGG | hsa:3579 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3579 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9888 | 4.7389 × 10-4 |
| Accuracy | 0.9696 | 0.0024 |
| Sensitivity | 0.9747 | 0.0036 |
| Specificity | 0.9652 | 0.0031 |
| BEDROC | 0.9988 | 0.0013 |
| MCC Threshold | 0.436 | N/A |
| MCC | 0.9434 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9697 | N/A |