TargetNet
P25024
C-X-C chemokine receptor type 1
Function
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
Database Links
| Database | Links |
|---|---|
| UniProt | P25024 |
| PDB | 1ILP, 1ILQ, 2LNL |
| BioGrid | 109791 |
| BindingDB | P25024 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 68 |
| PharmGKB | PA29842 |
| KEGG | hsa:3577 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3577 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.968 | 0.0054 |
| Accuracy | 0.9139 | 0.0052 |
| Sensitivity | 0.9123 | 0.0091 |
| Specificity | 0.9155 | 0.009 |
| BEDROC | 0.9992 | 0.0012 |
| MCC Threshold | 0.706 | N/A |
| MCC | 0.8408 | N/A |
| F-score Threshold | 0.346 | N/A |
| F-score | 0.9205 | N/A |