TargetNet
P25021
Histamine H2 receptor
Function
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P25021 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P25021 |
| DrugBank | DB00272, DB00501, DB01142, DB00751, DB00927, DB00667, DB00585, DB00863 |
| Guide to PHARMACOLOGY | 263 |
| PharmGKB | PA29457 |
| KEGG | hsa:3274 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3274 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9 | 0.0055 |
| Accuracy | 0.8402 | 0.006 |
| Sensitivity | 0.821 | 0.0121 |
| Specificity | 0.8589 | 0.006 |
| BEDROC | 0.9594 | 0.0125 |
| MCC Threshold | 0.48 | N/A |
| MCC | 0.6798 | N/A |
| F-score Threshold | 0.48 | N/A |
| F-score | 0.8367 | N/A |