TargetNet
P24530
Endothelin B receptor
Function
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P24530 |
| PDB | Not available |
| BioGrid | 108232 |
| BindingDB | P24530 |
| DrugBank | DB00559 |
| Guide to PHARMACOLOGY | 220 |
| PharmGKB | PA27618 |
| KEGG | hsa:1910 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1910 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9701 | 0.0013 |
| Accuracy | 0.9305 | 0.0029 |
| Sensitivity | 0.9391 | 0.0052 |
| Specificity | 0.9218 | 0.0041 |
| BEDROC | 0.9877 | 0.0065 |
| MCC Threshold | 0.472 | N/A |
| MCC | 0.8678 | N/A |
| F-score Threshold | 0.42 | N/A |
| F-score | 0.9349 | N/A |