TargetNet
P24468
COUP transcription factor 2
Function
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.
Database Links
| Database | Links |
|---|---|
| UniProt | P24468 |
| PDB | 3CJW |
| BioGrid | 112884 |
| BindingDB | P24468 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA31759 |
| KEGG | hsa:7026 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7026 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.7955 | 0.0105 |
| Accuracy | 0.7341 | 0.0122 |
| Sensitivity | 0.6628 | 0.0275 |
| Specificity | 0.7937 | 0.0183 |
| BEDROC | 0.8828 | 0.029 |
| MCC Threshold | 0.574 | N/A |
| MCC | 0.4727 | N/A |
| F-score Threshold | 0.456 | N/A |
| F-score | 0.7239 | N/A |