TargetNet
P23975
Sodium-dependent noradrenaline transporter
Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Database Links
| Database | Links |
|---|---|
| UniProt | P23975 |
| PDB | Not available |
| BioGrid | 112421 |
| BindingDB | P23975 |
| DrugBank | DB04836, DB00321, DB00543, DB00289, DB00217, DB01156, DB01242, DB00907, DB04840, DB01151, DB00937, DB01142, DB00476, DB00696, DB00226, DB01170, DB00458, DB00934, DB00579, DB00422, DB04896, DB01149, DB00368, DB00540, DB00715, DB00830, DB00191, DB00344, DB00234, DB01105, DB00193, DB00656, DB00726, DB00285 |
| Guide to PHARMACOLOGY | 926 |
| PharmGKB | PA310 |
| KEGG | hsa:6530 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6530 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9612 | 0.0012 |
| Accuracy | 0.9085 | 0.0018 |
| Sensitivity | 0.9271 | 0.0024 |
| Specificity | 0.8871 | 0.004 |
| BEDROC | 0.9883 | 0.0023 |
| MCC Threshold | 0.468 | N/A |
| MCC | 0.8194 | N/A |
| F-score Threshold | 0.468 | N/A |
| F-score | 0.9179 | N/A |