TargetNet
P23946
Chymase
Function
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Database Links
| Database | Links |
|---|---|
| UniProt | P23946 |
| PDB | 1KLT, 1NN6, 1PJP, 1T31, 2HVX, 3N7O, 3S0N, 4AFQ, 4AFS, 4AFU, 4AFZ, 4AG1, 4AG2, 4K2Y, 4K5Z, 4K60, 4K69, 4KP0 |
| BioGrid | 107624 |
| BindingDB | P23946 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2340 |
| PharmGKB | PA26623 |
| KEGG | hsa:1215 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1215 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.972 | 0.0023 |
| Accuracy | 0.9197 | 0.0034 |
| Sensitivity | 0.9279 | 0.0068 |
| Specificity | 0.9128 | 0.0051 |
| BEDROC | 0.9825 | 0.0045 |
| MCC Threshold | 0.52 | N/A |
| MCC | 0.8396 | N/A |
| F-score Threshold | 0.52 | N/A |
| F-score | 0.9142 | N/A |