TargetNet
P23458
Tyrosine-protein kinase JAK1
Function
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
Database Links
| Database | Links |
|---|---|
| UniProt | P23458 |
| PDB | 3EYG, 3EYH, 4E4L, 4E4N, 4E5W, 4EHZ, 4EI4, 4FK6, 4GS0, 4I5C, 4IVB, 4IVC, 4IVD, 4K6Z, 4K77, 4L00, 4L01 |
| BioGrid | 109919 |
| BindingDB | P23458 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 2047 |
| PharmGKB | PA29988 |
| KEGG | hsa:3716 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3716 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9534 | 0.003 |
| Accuracy | 0.8986 | 0.0052 |
| Sensitivity | 0.8802 | 0.0117 |
| Specificity | 0.9165 | 0.0042 |
| BEDROC | 0.9985 | 9.2154 × 10-4 |
| MCC Threshold | 0.51 | N/A |
| MCC | 0.8232 | N/A |
| F-score Threshold | 0.51 | N/A |
| F-score | 0.9091 | N/A |