TargetNet
P23385
Metabotropic glutamate receptor 1
Function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
Database Links
| Database | Links |
|---|---|
| UniProt | P23385 |
| PDB | 1EWK, 1EWT, 1EWV, 1ISR, 1ISS |
| BioGrid | 246579 |
| BindingDB | P23385 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 289 |
| PharmGKB | Not available |
| KEGG | rno:24414 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24414 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9756 | 0.003 |
| Accuracy | 0.932 | 0.0053 |
| Sensitivity | 0.935 | 0.0081 |
| Specificity | 0.9287 | 0.0052 |
| BEDROC | 0.9998 | 4.5736 × 10-5 |
| MCC Threshold | 0.574 | N/A |
| MCC | 0.8605 | N/A |
| F-score Threshold | 0.574 | N/A |
| F-score | 0.932 | N/A |