TargetNet
P23141
Liver carboxylesterase 1
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
Database Links
| Database | Links |
|---|---|
| UniProt | P23141 |
| PDB | 1MX1, 1MX5, 1MX9, 1YA4, 1YA8, 1YAH, 1YAJ, 2DQY, 2DQZ, 2DR0, 2H7C, 2HRQ, 2HRR, 3K9B, 4AB1 |
| BioGrid | 107494 |
| BindingDB | P23141 |
| DrugBank | DB00357, DB01393, DB01432, DB00691 |
| Guide to PHARMACOLOGY | 2592 |
| PharmGKB | PA107 |
| KEGG | hsa:1066 |
| BioCyc | MetaCyc:HS11616-MONOMER |
| Entrez Gene (GeneID) | 1066 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8784 | 0.0098 |
| Accuracy | 0.7956 | 0.0137 |
| Sensitivity | 0.8473 | 0.0212 |
| Specificity | 0.7391 | 0.0222 |
| BEDROC | 0.9621 | 0.0091 |
| MCC Threshold | 0.532 | N/A |
| MCC | 0.6148 | N/A |
| F-score Threshold | 0.532 | N/A |
| F-score | 0.8204 | N/A |