TargetNet
P22894
Neutrophil collagenase
Function
Can degrade fibrillar type I, II, and III collagens.
Database Links
| Database | Links |
|---|---|
| UniProt | P22894 |
| PDB | 1A85, 1A86, 1BZS, 1I73, 1I76, 1JAN, 1JAO, 1JAP, 1JAQ, 1JH1, 1JJ9, 1KBC, 1MMB, 1MNC, 1ZP5, 1ZS0, 1ZVX, 2OY2, 2OY4, 3DNG, 3DPE, 3DPF, 3TT4 |
| BioGrid | 110460 |
| BindingDB | P22894 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 1632 |
| PharmGKB | PA30888 |
| KEGG | hsa:4317 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 4317 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.981 | 0.001 |
| Accuracy | 0.9528 | 0.003 |
| Sensitivity | 0.962 | 0.0046 |
| Specificity | 0.9435 | 0.0042 |
| BEDROC | 0.9913 | 0.0029 |
| MCC Threshold | 0.512 | N/A |
| MCC | 0.9059 | N/A |
| F-score Threshold | 0.512 | N/A |
| F-score | 0.9536 | N/A |