TargetNet
P22748
Carbonic anhydrase 4
Function
Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.
Database Links
| Database | Links |
|---|---|
| UniProt | P22748 |
| PDB | 1ZNC, 3F7B, 3F7U, 3FW3 |
| BioGrid | 107217 |
| BindingDB | P22748 |
| DrugBank | DB00436, DB00562, DB00880, DB00606, DB01119, DB00999, DB00774, DB00232, DB01325, DB00273, DB01021 |
| Guide to PHARMACOLOGY | 2599 |
| PharmGKB | PA25991 |
| KEGG | hsa:762 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 762 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9083 | 0.0066 |
| Accuracy | 0.8585 | 0.0074 |
| Sensitivity | 0.7959 | 0.0094 |
| Specificity | 0.912 | 0.0104 |
| BEDROC | 0.992 | 0.0028 |
| MCC Threshold | 0.666 | N/A |
| MCC | 0.737 | N/A |
| F-score Threshold | 0.548 | N/A |
| F-score | 0.8465 | N/A |