Potassium voltage-gated channel subfamily A member 5
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.
Database | Links |
---|---|
UniProt | P22460 |
PDB | Not available |
BioGrid | 109943 |
BindingDB | P22460 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 542 |
PharmGKB | PA208 |
KEGG | hsa:3741 |
BioCyc | Not available |
Entrez Gene (GeneID) | 3741 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.979 | 0.0026 |
Accuracy | 0.9508 | 0.0035 |
Sensitivity | 0.9394 | 0.0059 |
Specificity | 0.9602 | 0.0047 |
BEDROC | 0.9985 | 5.4976 × 10-4 |
MCC Threshold | 0.354 | N/A |
MCC | 0.9042 | N/A |
F-score Threshold | 0.354 | N/A |
F-score | 0.9484 | N/A |