TargetNet
P22303
Acetylcholinesterase
Function
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
Database Links
| Database | Links |
|---|---|
| UniProt | P22303 |
| PDB | 1B41, 1F8U, 1PUV, 1PUW, 1VZJ, 2CLJ, 2X8B, 3LII, 4BDT, 4EY4, 4EY5, 4EY6, 4EY7, 4EY8, 4M0E, 4M0F |
| BioGrid | 106561 |
| BindingDB | P22303 |
| DrugBank | DB01122, DB00572, DB00122, DB01245, DB00944, DB00843, DB01010, DB01364, DB00674, DB00483, DB00677, DB01400, DB00981, DB00545, DB00989, DB00382, DB01199 |
| Guide to PHARMACOLOGY | 2465 |
| PharmGKB | PA20 |
| KEGG | hsa:43 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 43 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9276 | 0.0016 |
| Accuracy | 0.8695 | 0.0045 |
| Sensitivity | 0.8828 | 0.005 |
| Specificity | 0.8539 | 0.0068 |
| BEDROC | 0.9858 | 0.0032 |
| MCC Threshold | 0.51 | N/A |
| MCC | 0.7442 | N/A |
| F-score Threshold | 0.504 | N/A |
| F-score | 0.8834 | N/A |