TargetNet
P22086
Alpha-2C adrenergic receptor
Function
Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.
Database Links
| Database | Links |
|---|---|
| UniProt | P22086 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P22086 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 27 |
| PharmGKB | Not available |
| KEGG | rno:24175 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 24175 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8543 | 0.0142 |
| Accuracy | 0.7979 | 0.0162 |
| Sensitivity | 0.8309 | 0.0198 |
| Specificity | 0.7616 | 0.0188 |
| BEDROC | 0.9102 | 0.027 |
| MCC Threshold | 0.524 | N/A |
| MCC | 0.5823 | N/A |
| F-score Threshold | 0.478 | N/A |
| F-score | 0.8062 | N/A |