P22001

Potassium voltage-gated channel subfamily A member 3

Function

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Database Links

Database	Links
UniProt	P22001
PDB	4BGC
BioGrid	109941
BindingDB	P22001
DrugBank	Not available
Guide to PHARMACOLOGY	540
PharmGKB	PA30021
KEGG	hsa:3738
BioCyc	Not available
Entrez Gene (GeneID)	3738

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.921	0.0049
Accuracy	0.864	0.0083
Sensitivity	0.9041	0.0166
Specificity	0.8152	0.0059
BEDROC	0.9849	0.009
MCC Threshold	0.388	N/A
MCC	0.7384	N/A
F-score Threshold	0.388	N/A
F-score	0.8873	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Download RData

Positive Set

SMILES string + affinity value (.tsv)

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TargetNet