TargetNet
P21917
D(4) dopamine receptor
Function
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | P21917 |
| PDB | Not available |
| BioGrid | 108149 |
| BindingDB | P21917 |
| DrugBank | DB00714, DB00363, DB00334, DB00413, DB00420, DB00777, DB00268, DB00372, DB00246 |
| Guide to PHARMACOLOGY | 217 |
| PharmGKB | PA27480 |
| KEGG | hsa:1815 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1815 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9425 | 0.0017 |
| Accuracy | 0.8898 | 0.0028 |
| Sensitivity | 0.9031 | 0.0062 |
| Specificity | 0.8776 | 0.0017 |
| BEDROC | 0.9251 | 0.0074 |
| MCC Threshold | 0.448 | N/A |
| MCC | 0.7876 | N/A |
| F-score Threshold | 0.448 | N/A |
| F-score | 0.8917 | N/A |