TargetNet
P21836
Acetylcholinesterase
Function
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Database Links
| Database | Links |
|---|---|
| UniProt | P21836 |
| PDB | 1C2B, 1C2O, 1J06, 1J07, 1KU6, 1MAA, 1MAH, 1N5M, 1N5R, 1Q83, 1Q84, 2C0P, 2C0Q, 2GYU, 2GYV, 2GYW, 2H9Y, 2HA0, 2HA2, 2HA3, 2HA4, 2HA5, 2HA6, 2HA7, 2JEY, 2JEZ, 2JF0, 2JGE, 2JGF, 2JGI, 2JGJ, 2JGK, 2JGL, 2JGM, 2WHP, 2WHQ, 2WHR, 2WLS, 2WU3, 2WU4, 2XUD, 2XUF, 2XUG, 2XUH, 2XUI, 2XUJ, 2XUK, 2XUO, 2XUP, 2XUQ, 2Y2U, 2Y2V, 3DL4, 3DL7, 3ZLT, 3ZLU, 3ZLV, 4A16, 4A23, 4ARA, 4ARB, 4B7Z, 4B80, 4B81, 4B82, 4B83, 4B84, 4B85, 4BC0, 4BC1, 4BTL |
| BioGrid | 197921 |
| BindingDB | P21836 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | mmu:11423 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 11423 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8957 | 0.0068 |
| Accuracy | 0.8839 | 0.0073 |
| Sensitivity | 0.853 | 0.0053 |
| Specificity | 0.9105 | 0.012 |
| BEDROC | 0.9316 | 0.0216 |
| MCC Threshold | 0.55 | N/A |
| MCC | 0.7899 | N/A |
| F-score Threshold | 0.488 | N/A |
| F-score | 0.8828 | N/A |