TargetNet
P21731
Thromboxane A2 receptor
Function
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase.
Database Links
| Database | Links |
|---|---|
| UniProt | P21731 |
| PDB | 1LBN |
| BioGrid | 112777 |
| BindingDB | P21731 |
| DrugBank | DB01207 |
| Guide to PHARMACOLOGY | 346 |
| PharmGKB | PA348 |
| KEGG | hsa:6915 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6915 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9752 | 0.0013 |
| Accuracy | 0.9413 | 0.0024 |
| Sensitivity | 0.9357 | 0.0043 |
| Specificity | 0.946 | 0.003 |
| BEDROC | 0.9868 | 0.0057 |
| MCC Threshold | 0.538 | N/A |
| MCC | 0.8806 | N/A |
| F-score Threshold | 0.538 | N/A |
| F-score | 0.9349 | N/A |