TargetNet
P21554
Cannabinoid receptor 1
Function
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Database Links
| Database | Links |
|---|---|
| UniProt | P21554 |
| PDB | 1LVQ, 1LVR, 2B0Y, 2KOE |
| BioGrid | 107668 |
| BindingDB | P21554 |
| DrugBank | DB00470, DB00486, DB06155 |
| Guide to PHARMACOLOGY | 56 |
| PharmGKB | PA26681 |
| KEGG | hsa:1268 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 1268 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9737 | 8.9138 × 10-4 |
| Accuracy | 0.9328 | 0.0018 |
| Sensitivity | 0.9188 | 0.0023 |
| Specificity | 0.9445 | 0.0023 |
| BEDROC | 0.9958 | 0.0011 |
| MCC Threshold | 0.436 | N/A |
| MCC | 0.8663 | N/A |
| F-score Threshold | 0.436 | N/A |
| F-score | 0.9278 | N/A |