TargetNet
P21452
Substance-K receptor
Function
This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
Database Links
| Database | Links |
|---|---|
| UniProt | P21452 |
| PDB | Not available |
| BioGrid | 112728 |
| BindingDB | P21452 |
| DrugBank | DB00575, DB00104 |
| Guide to PHARMACOLOGY | 361 |
| PharmGKB | PA36303 |
| KEGG | hsa:6865 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6865 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9825 | 0.0018 |
| Accuracy | 0.953 | 0.0036 |
| Sensitivity | 0.9522 | 0.0061 |
| Specificity | 0.9538 | 0.0032 |
| BEDROC | 0.9944 | 0.0048 |
| MCC Threshold | 0.542 | N/A |
| MCC | 0.9129 | N/A |
| F-score Threshold | 0.542 | N/A |
| F-score | 0.9577 | N/A |