TargetNet
P21451
Endothelin B receptor
Function
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Database Links
| Database | Links |
|---|---|
| UniProt | P21451 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P21451 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 220 |
| PharmGKB | Not available |
| KEGG | rno:50672 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 50672 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8383 | 0.0161 |
| Accuracy | 0.7812 | 0.0146 |
| Sensitivity | 0.8145 | 0.0161 |
| Specificity | 0.7434 | 0.0248 |
| BEDROC | 0.9557 | 0.0123 |
| MCC Threshold | 0.588 | N/A |
| MCC | 0.6022 | N/A |
| F-score Threshold | 0.484 | N/A |
| F-score | 0.8112 | N/A |