TargetNet
P21397
Amine oxidase [flavin-containing] A
Function
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Database Links
| Database | Links |
|---|---|
| UniProt | P21397 |
| PDB | 1H8Q, 2BXR, 2BXS, 2Z5X, 2Z5Y |
| BioGrid | 110301 |
| BindingDB | P21397 |
| DrugBank | DB00918, DB00190, DB01068, DB00988, DB00176, DB01381, DB00458, DB01247, DB01235, DB00601, DB00186, DB01171, DB00184, DB00368, DB00780, DB00830, DB00191, DB00388, DB00397, DB00852, DB01367, DB00140, DB00953, DB01037, DB00669, DB00624, DB00752, DB00315 |
| Guide to PHARMACOLOGY | 2489 |
| PharmGKB | PA236 |
| KEGG | hsa:4128 |
| BioCyc | MetaCyc:HS01798-MONOMER |
| Entrez Gene (GeneID) | 4128 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8985 | 0.0033 |
| Accuracy | 0.8131 | 0.0068 |
| Sensitivity | 0.8078 | 0.0097 |
| Specificity | 0.8184 | 0.0084 |
| BEDROC | 0.9779 | 0.0085 |
| MCC Threshold | 0.618 | N/A |
| MCC | 0.6373 | N/A |
| F-score Threshold | 0.42 | N/A |
| F-score | 0.8168 | N/A |