TargetNet
P21396
Amine oxidase [flavin-containing] A
Function
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
Database Links
| Database | Links |
|---|---|
| UniProt | P21396 |
| PDB | 1O5W |
| BioGrid | Not available |
| BindingDB | P21396 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | Not available |
| BioCyc | MetaCyc:MONOMER-14994 |
| Entrez Gene (GeneID) | Not available |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8979 | 0.0047 |
| Accuracy | 0.8166 | 0.0076 |
| Sensitivity | 0.8116 | 0.0067 |
| Specificity | 0.8217 | 0.0112 |
| BEDROC | 0.9892 | 0.0023 |
| MCC Threshold | 0.52 | N/A |
| MCC | 0.6423 | N/A |
| F-score Threshold | 0.404 | N/A |
| F-score | 0.8266 | N/A |