TargetNet
P20701
Integrin alpha-L
Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
Database Links
| Database | Links |
|---|---|
| UniProt | P20701 |
| PDB | 1CQP, 1DGQ, 1IJ4, 1LFA, 1MJN, 1MQ8, 1MQ9, 1MQA, 1RD4, 1T0P, 1XDD, 1XDG, 1XUO, 1ZON, 1ZOO, 1ZOP, 2ICA, 2K8O, 2M3E, 2O7N, 3BN3, 3BQM, 3BQN, 3E2M, 3EOA, 3EOB, 3F74, 3F78, 3HI6, 3M6F, 3TCX, 4IXD |
| BioGrid | 109889 |
| BindingDB | P20701 |
| DrugBank | DB00095 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA29948 |
| KEGG | hsa:3683 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 3683 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9605 | 0.0028 |
| Accuracy | 0.9025 | 0.0067 |
| Sensitivity | 0.9175 | 0.0066 |
| Specificity | 0.8851 | 0.009 |
| BEDROC | 0.9992 | 3.7302 × 10-4 |
| MCC Threshold | 0.516 | N/A |
| MCC | 0.8268 | N/A |
| F-score Threshold | 0.516 | N/A |
| F-score | 0.9195 | N/A |