TargetNet
P20648
Potassium-transporting ATPase alpha chain 1
Function
Catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. Responsible for acid production in the stomach.
Database Links
| Database | Links |
|---|---|
| UniProt | P20648 |
| PDB | Not available |
| BioGrid | 106985 |
| BindingDB | P20648 |
| DrugBank | DB00736, DB00448, DB00338, DB00213, DB01129, DB00831 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA25113 |
| KEGG | hsa:495 |
| BioCyc | MetaCyc:HS02790-MONOMER |
| Entrez Gene (GeneID) | 495 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.8872 | 0.0063 |
| Accuracy | 0.8257 | 0.0111 |
| Sensitivity | 0.8268 | 0.0209 |
| Specificity | 0.8247 | 0.0131 |
| BEDROC | 0.9635 | 0.0214 |
| MCC Threshold | 0.526 | N/A |
| MCC | 0.6689 | N/A |
| F-score Threshold | 0.518 | N/A |
| F-score | 0.8218 | N/A |