Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
Database | Links |
---|---|
UniProt | P20309 |
PDB | 2CSA |
BioGrid | 107553 |
BindingDB | P20309 |
DrugBank | DB00517, DB00572, DB00767, DB00185, DB00785, DB01176, DB00496, DB00729, DB01231, DB00725, DB01403, DB00340, DB00334, DB01062, DB00383, DB00420, DB01069, DB00777, DB01591, DB00372, DB01409, DB01036, DB00505 |
Guide to PHARMACOLOGY | 15 |
PharmGKB | PA112 |
KEGG | hsa:1131 |
BioCyc | Not available |
Entrez Gene (GeneID) | 1131 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9561 | 9.5698 × 10-4 |
Accuracy | 0.8941 | 0.0031 |
Sensitivity | 0.9067 | 0.0049 |
Specificity | 0.8797 | 0.0046 |
BEDROC | 0.9958 | 0.0014 |
MCC Threshold | 0.538 | N/A |
MCC | 0.7951 | N/A |
F-score Threshold | 0.538 | N/A |
F-score | 0.9028 | N/A |