TargetNet
P20292
Arachidonate 5-lipoxygenase-activating protein
Function
Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Database Links
| Database | Links |
|---|---|
| UniProt | P20292 |
| PDB | 2Q7M, 2Q7R |
| BioGrid | 106742 |
| BindingDB | P20292 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA47 |
| KEGG | hsa:241 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 241 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9834 | 0.0014 |
| Accuracy | 0.9703 | 0.0026 |
| Sensitivity | 0.9688 | 0.0038 |
| Specificity | 0.9717 | 0.0043 |
| BEDROC | 0.9923 | 0.0052 |
| MCC Threshold | 0.33 | N/A |
| MCC | 0.9512 | N/A |
| F-score Threshold | 0.33 | N/A |
| F-score | 0.9751 | N/A |