TargetNet
P20272
Cannabinoid receptor 1
Function
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current.
Database Links
| Database | Links |
|---|---|
| UniProt | P20272 |
| PDB | Not available |
| BioGrid | 247288 |
| BindingDB | P20272 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | 56 |
| PharmGKB | Not available |
| KEGG | rno:25248 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 25248 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9867 | 6.2299 × 10-4 |
| Accuracy | 0.953 | 0.0023 |
| Sensitivity | 0.9512 | 0.0038 |
| Specificity | 0.955 | 0.0017 |
| BEDROC | 0.9988 | 0.0015 |
| MCC Threshold | 0.43 | N/A |
| MCC | 0.9138 | N/A |
| F-score Threshold | 0.43 | N/A |
| F-score | 0.9582 | N/A |