TargetNet
P20231
Tryptase beta-2
Function
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P20231 |
| PDB | 1A0L, 1AAO, 2BM2, 2FPZ, 2FS8, 2FS9, 2FWW, 2FXR, 2GDD, 2ZA5, 3V7T |
| BioGrid | 113029, 122201 |
| BindingDB | P20231 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA36698 |
| KEGG | hsa:64499, hsa:7177 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 64499, 7177 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.98 | 0.0027 |
| Accuracy | 0.9394 | 0.0054 |
| Sensitivity | 0.9282 | 0.0082 |
| Specificity | 0.949 | 0.0096 |
| BEDROC | 0.9993 | 0.0013 |
| MCC Threshold | 0.656 | N/A |
| MCC | 0.8739 | N/A |
| F-score Threshold | 0.47 | N/A |
| F-score | 0.9284 | N/A |