TargetNet
P19634
Sodium/hydrogen exchanger 1
Function
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Database Links
| Database | Links |
|---|---|
| UniProt | P19634 |
| PDB | 1Y4E, 2BEC, 2E30, 2HTG, 2KBV, 2L0E, 2YGG |
| BioGrid | 112438 |
| BindingDB | P19634 |
| DrugBank | DB00594 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA35928 |
| KEGG | hsa:6548 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6548 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9521 | 0.0041 |
| Accuracy | 0.8935 | 0.0072 |
| Sensitivity | 0.9223 | 0.0087 |
| Specificity | 0.866 | 0.0105 |
| BEDROC | 0.9807 | 0.0078 |
| MCC Threshold | 0.564 | N/A |
| MCC | 0.7737 | N/A |
| F-score Threshold | 0.298 | N/A |
| F-score | 0.8866 | N/A |