5-hydroxytryptamine receptor 1A
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Database | Links |
---|---|
UniProt | P19327 |
PDB | Not available |
BioGrid | Not available |
BindingDB | P19327 |
DrugBank | Not available |
Guide to PHARMACOLOGY | 1 |
PharmGKB | Not available |
KEGG | rno:24473 |
BioCyc | Not available |
Entrez Gene (GeneID) | 24473 |
Metric | Mean Value | Standard Deviation |
---|---|---|
AUC | 0.9838 | 5.7023 × 10-4 |
Accuracy | 0.9462 | 0.0013 |
Sensitivity | 0.9517 | 0.0021 |
Specificity | 0.9414 | 0.0019 |
BEDROC | 0.9918 | 9.1776 × 10-4 |
MCC Threshold | 0.534 | N/A |
MCC | 0.8909 | N/A |
F-score Threshold | 0.534 | N/A |
F-score | 0.9417 | N/A |