TargetNet
P19320
Vascular cell adhesion protein 1
Function
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Database Links
| Database | Links |
|---|---|
| UniProt | P19320 |
| PDB | 1IJ9, 1VCA, 1VSC |
| BioGrid | 113255 |
| BindingDB | P19320 |
| DrugBank | DB01136 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA37286 |
| KEGG | hsa:7412 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 7412 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9634 | 0.003 |
| Accuracy | 0.9304 | 0.0062 |
| Sensitivity | 0.9348 | 0.0039 |
| Specificity | 0.9252 | 0.0106 |
| BEDROC | 0.9732 | 0.0066 |
| MCC Threshold | 0.66 | N/A |
| MCC | 0.8752 | N/A |
| F-score Threshold | 0.638 | N/A |
| F-score | 0.9403 | N/A |