TargetNet
P19099
Cytochrome P450 11B2, mitochondrial
Function
Preferentially catalyzes the conversion of 11- deoxycorticosterone to aldosterone via corticosterone and 18- hydroxycorticosterone.
Database Links
| Database | Links |
|---|---|
| UniProt | P19099 |
| PDB | 4DVQ, 4FDH |
| BioGrid | 107957 |
| BindingDB | P19099 |
| DrugBank | DB00796, DB01011 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA134 |
| KEGG | hsa:1585 |
| BioCyc | MetaCyc:HS11355-MONOMER |
| Entrez Gene (GeneID) | 1585 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9973 | 6.048 × 10-4 |
| Accuracy | 0.9828 | 0.0016 |
| Sensitivity | 0.9889 | 0.0023 |
| Specificity | 0.9773 | 0.0021 |
| BEDROC | 0.9941 | 0.0046 |
| MCC Threshold | 0.62 | N/A |
| MCC | 0.9746 | N/A |
| F-score Threshold | 0.62 | N/A |
| F-score | 0.9867 | N/A |