P18825

Alpha-2C adrenergic receptor

Function

Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.

Database Links

Database	Links
UniProt	P18825
PDB	Not available
BioGrid	106661
BindingDB	P18825
DrugBank	DB00217, DB00484, DB04840, DB00800, DB00226, DB01170, DB04948, DB00368, DB01392
Guide to PHARMACOLOGY	27
PharmGKB	PA37
KEGG	hsa:152
BioCyc	Not available
Entrez Gene (GeneID)	152

Chemical Space of the Positive Compounds

Model Performance Metrics

Metric	Mean Value	Standard Deviation
AUC	0.9453	0.0029
Accuracy	0.8716	0.0093
Sensitivity	0.8397	0.0125
Specificity	0.9016	0.0098
BEDROC	0.9898	0.0021
MCC Threshold	0.52	N/A
MCC	0.7458	N/A
F-score Threshold	0.428	N/A
F-score	0.8712	N/A

Downloads

R Model Object

Random Forest model object (.RData)

Positive Set

SMILES string + affinity value (.tsv)