TargetNet
P18405
3-oxo-5-alpha-steroid 4-dehydrogenase 1
Function
Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5- alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Database Links
| Database | Links |
|---|---|
| UniProt | P18405 |
| PDB | Not available |
| BioGrid | 112593 |
| BindingDB | P18405 |
| DrugBank | DB01126, DB01216 |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | PA36112 |
| KEGG | hsa:6715 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 6715 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9857 | 0.0026 |
| Accuracy | 0.9556 | 0.0035 |
| Sensitivity | 0.9566 | 0.0085 |
| Specificity | 0.9547 | 0.0028 |
| BEDROC | 0.9981 | 0.0014 |
| MCC Threshold | 0.554 | N/A |
| MCC | 0.9207 | N/A |
| F-score Threshold | 0.554 | N/A |
| F-score | 0.957 | N/A |