TargetNet
P18130
Alpha-1A adrenergic receptor
Function
This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).
Database Links
| Database | Links |
|---|---|
| UniProt | P18130 |
| PDB | Not available |
| BioGrid | Not available |
| BindingDB | P18130 |
| DrugBank | Not available |
| Guide to PHARMACOLOGY | Not available |
| PharmGKB | Not available |
| KEGG | bta:282134 |
| BioCyc | Not available |
| Entrez Gene (GeneID) | 282134 |
Chemical Space of the Positive Compounds
Model Performance Metrics
| Metric | Mean Value | Standard Deviation |
|---|---|---|
| AUC | 0.9289 | 0.009 |
| Accuracy | 0.8475 | 0.012 |
| Sensitivity | 0.8799 | 0.0189 |
| Specificity | 0.8071 | 0.0172 |
| BEDROC | 0.9861 | 0.0084 |
| MCC Threshold | 0.404 | N/A |
| MCC | 0.697 | N/A |
| F-score Threshold | 0.404 | N/A |
| F-score | 0.8727 | N/A |